Miele S7580 vs S7260
images from manufacturer

S7580 has a few models, there are 2 available on mielestore.com: S7580 AutoEco and the S7580 Swing.

The difference between Miele S7260 vs S7580 are:

Price: S7260 is cheaper.
The s7260 is priced at $649 at http://mielestore.com, whiel S7580 AutoEco is priced at $749 and S7580 Swing is priced at $849.00 on 2013-04-28.

Number of Power Settings:
The S7260 has 4 settings while the S7580 has 6 settings.
The S7260 uses rotary dial to control suction, while the S7580 AutoEco and S7580 Swing use +/- control buttons to select suction power.

Automatic Motor Setting:
The S7580 features automatic motor setting for suction while the S7260 doesn’t.

Included Filter:
The S7260 includes the Active Air Clean Filter while the S7580 comes with Active HEPA Filter.

Filter Change Indicator:
The S7580 has a filter change indicator light to let you know when to change the filter, while the S7260 does not have.

Mini Turbo Brush:
The S7260 comes with a air powered turbo brush while the S7580 does not include this attachment.

Microset and Flexible Crevice Tool:
The S7580 Swing comes with a Microset and Flexible Crevice Tool for thorough cleaning, while the S7580 AutoEco and S7260 do not include.

Color:
The S7260 is in Lotus White, while the S7580 AutoEco is in Obsidian Black and S7580 Swing is in Steel Blue Metallic.

If you know more difference between Miele S7260 and S7580 vacuum cleaners, please share below.